What is COIN

COIN is a global research consortium established in 2019 as a common platform connecting like-minded researchers worldwide. We aim to contribute to the progress of eye research for many years to come.

Recent activities of the COIN consortium

Key publications

Title Journal Year
Choroidal vascularity index: a step towards software as a medical device. Br J Ophthalmol 2022
Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease. Ophthalmol Retina 2022
Choroidal Microvascular Alterations in COVID-19 Patients. Ocul Immunol Inflamm 2022
Three-dimensional modelling of the choroidal angioarchitecture in a multi-ethnic Asian population. Sci Rep 2022
Choroidal and Retinal Changes After Systemic Adrenaline and Photodynamic Therapy in Non-Human Primates. Invest Ophthalmol Vis Sci 2021
Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease. JAMA Ophthalmol 2021
Choroidal Structural Analysis in Alzheimer Disease, Mild Cognitive Impairment, and Cognitively Healthy Controls. Am J Ophthalmol 2021
Choroidal Structural Changes in Patients with Birdshot Chorioretinopathy. Ocul Immunol Inflamm 2021
Choroidal Structural Changes in Sympathetic Ophthalmia on Swept-Source Optical Coherence Tomography. Ocul Immunol Inflamm 2021
Normal aging changes in the choroidal angioarchitecture of the macula. Sci Rep 2020
Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. Prog Retin Eye Res 2020
Choroidal Structural Changes in Smokers Measured Using Choroidal Vascularity Index. Invest Ophthalmol Vis Sci 2019
Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy. Invest Ophthalmol Vis Sci 2019
Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration. Sci Rep 2019
Choroidal structural analysis and vascularity index in retinal dystrophies. Acta Ophthalmol 2019
Choroidal structural changes in preterm children with and without retinopathy of prematurity. Acta Ophthalmol 2019
Peripapillary Choroidal Vascularity Index in Glaucoma-A Comparison Between Spectral-Domain OCT and OCT Angiography. Invest Ophthalmol Vis Sci 2018
Comparison of Choroidal Vascularity Markers on Optical Coherence Tomography Using Two-Image Binarization Techniques. Invest Ophthalmol Vis Sci 2018
Choroidal vascularity index changes after vitreomacular surgery. Acta Ophthalmol 2018
Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-A novel OCT based imaging biomarker. PLoS One 2018
Choroidal vascular changes in age-related macular degeneration. Acta Ophthalmol 2017
CHOROIDAL VASCULARITY INDEX: A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration. Retina 2017
Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study. Sci Rep 2017
Influence of scanning area on choroidal vascularity index measurement using optical coherence tomography. Acta Ophthalmol 2017
Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year. Invest Ophthalmol Vis Sci 2016
Choroidal vascularity index - a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus? Acta Ophthalmol 2016
Choroidal Vascularity Index in Vogt-Koyanagi-Harada Disease: An EDI-OCT Derived Tool for Monitoring Disease Progression. Transl Vis Sci Technol 2016
State of science: Choroidal thickness and systemic health. Surv Ophthalmol 2016
Choroidal Vascularity Index (CVI)–A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis? PLoS One 2016
Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci Rep 2016

Grants awarded

Name of grant Project Year Obtained
Ng Teng Fong Healthcare Innovation Program Grant CVI 2019
National Medical Research Council New Investigator Grant OCTOMERIA 2019
Ng Teng Fong Healthcare Innovation Programme Grant VHI 2020
NHG-LKC Medicine Clinician Scientist Preparatory Programme CVI-HELIOS 2022
National Medical Research Council CS-IRG grant SaMD 2022

Important Documents

All CVIgrid users are to read thoroughly and sign the CVI Grid handbook and Consortium agreement. After signing, the documents can be sent to cvi.grid@gmail.com to obtain membership and access to image analysis platform for CVI.

CVI Grid HandbookDownload
Consortium Agreement for CVI Grid Download
CVI Grid BrochureDownload